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This is significantly longer than the few seconds of endogenous -MSH, but remains short compared to long-acting analogs such as subcutaneous afamelanotide implant (release over 60 days)

Stroke 42 , 23262329 (2011)

A similar feedback loop is observed with Epidermal Growth Factor Receptor (EGFR), whose expression is increased by SOX2, thus fostering EGFR signalling, which in turn increases SOX2 expression (Shimozaki, 2014)

For particularly sensitive peptides, a shorter recommended use window might be advised, but optimal storage significantly extends usability

Such findings hint at Ipamorelin's potential to boost the pace of gastric emptying